Having a brother or sister with LFS


By Louis Pantziarka When I was twelve years old my older brother, George, died of cancer. It sounds obvious that something like that would change you and yet at the time you don’t see it. Life goes on around you, … Read More

Attitudes to Whole-body MRI


Have you had or been offered Whole-Body MRI screening? Have you been offered it and declined? We are seeking individuals who have had or been offered Whole-Body MRI (WB-MRI) screening in the UK. If you have a clinical and/or genetic … Read More

LFS Surveillance Protocol – Write to Your MP


The national LFS surveillance protocol, agreed in July 2018, has still not been rolled out nationally across the NHS. Discussions on funding are taking longer than expected, and as reported by Dr Helen Hanson at our LFS UK 2019 meeting, … Read More

Whole-body MRI – Guest post by Dr Andrew Gogbashian


A recent study in JAMA Oncology has highlighted the benefits of screening patients with Li-Fraumeni syndrome using whole-body MRI imaging. The study demonstrates that screening with whole-body MRI enables clinically useful early detection of cancer in TP53 mutation carriers. The … Read More

LFS Research Project – Reducing cancer risk


The previous article outlined how p53 isoforms are changing our view on how TP53 is involved in so many different functions in the cell. Where we used to think there was only one p53 protein doing everything, we now know … Read More

LFS Research Project – p53 isoforms


The scientific understanding of TP53 continues to evolve and change – while it’s still known primarily because of its function in tumour suppression, we also know that it is central to how cells respond to an increasingly wide range of … Read More

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