By Louis Pantziarka When I was twelve years old my older brother, George, died of cancer. It sounds obvious that something like that would change you and yet at the time you don’t see it. Life goes on around you, … Read More
Have you had or been offered Whole-Body MRI screening? Have you been offered it and declined? We are seeking individuals who have had or been offered Whole-Body MRI (WB-MRI) screening in the UK. If you have a clinical and/or genetic … Read More
A clinical trial of the antidiabetic drug metformin is being developed for adults with Li Fraumeni Syndrome (LFS). This is the MILI trial – which we’ve discussed before. The trial aims to test whether metformin can reduce the incidence of … Read More
Chemotherapy is hard on kids, as any parent of a child who has had cancer treatment can confirm. For parents of children with Li Fraumeni Syndrome (LFS) we try and not to think too much about what the long-term effects … Read More
The national LFS surveillance protocol, agreed in July 2018, has still not been rolled out nationally across the NHS. Discussions on funding are taking longer than expected, and as reported by Dr Helen Hanson at our LFS UK 2019 meeting, … Read More
A recent study in JAMA Oncology has highlighted the benefits of screening patients with Li-Fraumeni syndrome using whole-body MRI imaging. The study demonstrates that screening with whole-body MRI enables clinically useful early detection of cancer in TP53 mutation carriers. The … Read More
The previous article outlined how p53 isoforms are changing our view on how TP53 is involved in so many different functions in the cell. Where we used to think there was only one p53 protein doing everything, we now know … Read More
The scientific understanding of TP53 continues to evolve and change – while it’s still known primarily because of its function in tumour suppression, we also know that it is central to how cells respond to an increasingly wide range of … Read More
One of the most important questions for people with LFS is whether there is anything that can be done to reduce the risks of developing cancer. Is there something in diet, exercise or lifestyle that can reduce the risks? One … Read More
One of the most contentious issues for people dealing with Li Fraumeni Syndrome is screening – the active program of checking for cancers before any symptoms become evident. The idea is simple enough – if we can catch cancer before … Read More